3Rs Webinar Archive

3Rs Webinar Archive

With the growing emphasis on alternative approaches and the implementation of the 3Rs in biomedical research, NJABR has developed the 3Rs Webinar Series. This platform provides neutral forums where the scientific community can share best practices and evidence-based approaches that speed the science and improve animal welfare.

If you missed the original webcasts, here is your opportunity to obtain each series. Each series of three webinars is now available online for $300.

Webinar #1 Defining Metrics & Assessing the 3Rs
Presentation Summary
•Key points from EFPIA 3Rs survey
•Background to 3Rs KPI project
•Difficulties in defining common 3Rs KPIs
•Output from 3Rs KPIs project
•EFPIAs plans for 3Rs/Welfare report

Gill Fleetwood
EFPIA Research & Animal Welfare Group
Director EU Animal Welfare Liaison, GlaxoSmithKline, UK
Magda Chlebus
Director Science Policy, EFPIA
Original webcast: April 24, 2012

Webinar #2 Integration of New Drug Development Tools into the FDA Regulatory Framework
Presentation Summary
•FDA’s efforts to encourage development of new Drug Discovery Tools (DDTs), including improved biomarkers, patient-reported outcomes, and animal models
•Incorporating DDTs into drug development
•Examples of how FDA is using genomics and other new scientific tools to improve the safe and effective use of drugs
•Challenges to the development of DDTs and the power of collaborative models in this area

Presenter: Douglas Throckmorton, MD, PhD
Deputy Director, FDA Center for Drug Evaluation & Research
Original webcast: May 22, 2012

Webinar #3 Examining and Affecting a Culture of Refinement of Animal Care and Use within Your Organization
Presentation Summary
• Methods for examining the practices and culture within your organization relating to animal care and use
• Approaches for obtaining honest, challenging, and useful feedback from a wide variety of stakeholders, including executives, managers, researchers, and care staff
• Strategy design and implementation

Presenter: D. Kemp Covington, DVM
Manager, Comparative Medicine and Investigator Support
Original Webcast: June 14, 2012

Webinar #4  Crack-ing 3Rs Challenges
Presentation Summary
• Win/Win strategies that cross corporate, country cultures
• Collaborations bridging the industry/academia divide
• NC3Rs program highlights & successes

Presenters: Kathryn Chapman, PhD
Original webcast: September 20, 2012

Webinar #5  Humanized Mice: Impact on the Drug Attrition Rate & 3Rs
Presentation Summary
– Looking at drug-drug interactions through the use of humanized mice for ADME;
– Studying human-specific metabolites using humanized CYP mice;
– Observing liver uptake and toxicity utilizing humanized OATP mice; and
– Using humanized rasH2 mice to reduce the number of animals needed for carcinogenicity testing.

Presenter: Sandra Petralia, PhD
Business Development Manager • Taconic
Original webcast: October 25, 2012

Webinar #6 Biomarkers & The Implications for 3Rs
Presentation Summary
• FDA partnerships to speed the identification of acceptable models, refine current tools, & the qualification process
• Working on biomarkers in the pre-competitive space; the advantages & opportunities; disadvantages;
• Implications for the use of qualified biomarkers for the reduction, refinement and replacement of animals in research

Presenter: Marc Walton, MD, PhD
Associate Director, Office of Translational Science, FDA, CDER
Original Webcast: November 13, 2012

Webinar #7 Antimicrobial Drug Discovery: Finding the Straightest Road from Bench to Bedside
Presentation Summary
• Discuss the challenges of antibacterial drug development
• Review successes and failures of replacement strategies
• Discuss the use of humanized models to maximize clinical predictability

Presenter: Jared Crandon, PharmD
Associate Director, Clinical & Experimental Pharmacology, Hartford Hospital
Original Webcast: April 3, 2013

Webinar #8 IQ3Rs LG Benchmarking Survey:  Strengths, Opportunities and Next Steps
Presentation Summary
• Results from 3Rs benchmarking survey conducted across 15 biopharmaceutical companies
• Industry 3Rs strengths/consistencies
• 3Rs opportunities/inconsistencies

Presenter: Letty Medina, DVM,
Associate Director, Animal Welfare & Compliance, Abbvie & Chair, IQ 3Rs Leadership Group
Original Webcast: May 7, 2013

Webinar#9 An In Vitro Biomimetic Immune System (MIMIC): Helping to Find the Black Cat in the Dark Room
Presentation Summary
• Do in vitro responses mimic in vivo (human) responses?
• How reproducible is the MIMIC system?
• What are the limitations of the system?
• What is the usefulness of the MIMIC system in vaccine and drug development?

Presenter: William Warren, PhD
Vice President & Head, VaxDesign campus of Sanofi Pasteur
Original Webcast: June 12, 2013

Contact Eileen at 609-392-0155 to purchase this innovative webinar series.

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